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PSMD2 contributes to the progression of esophageal squamous cell carcinoma by repressing autophagy.
Liu Y, Wu M, Xu S, Niu X, Liu W, Miao C, Lin A, Xu Y, Yu L. Liu Y, et al. Cell Biosci. 2023 Mar 30;13(1):67. doi: 10.1186/s13578-023-01016-4. Cell Biosci. 2023. PMID: 36998052 Free PMC article.
BACKGROUND: The ubiquitin-proteasome and autophagy-lysosomal systems collaborate in regulating the levels of intracellular proteins. Dysregulation of protein homeostasis is a central feature of malignancy. The gene encoding 26S proteasome non-ATPase …
BACKGROUND: The ubiquitin-proteasome and autophagy-lysosomal systems collaborate in regulating the levels of intracellular proteins. Dysregu …
Prognostic Implication and Immunological Role of PSMD2 in Lung Adenocarcinoma.
Zhao H, Lu G. Zhao H, et al. Front Genet. 2022 Jun 8;13:905581. doi: 10.3389/fgene.2022.905581. eCollection 2022. Front Genet. 2022. PMID: 35754829 Free PMC article.
Background: Although previous studies reported that 26S proteasome non-ATPase regulatory subunit 2 (PSMD2) is involved in many human cancers. ...Results: Both mRNA and protein expression of PSMD2 were significa …
Background: Although previous studies reported that 26S proteasome non-ATPase regulatory subunit …
Diverse Ras-related GTPase DIRAS2, downregulated by PSMD2 in a proteasome-mediated way, inhibits colorectal cancer proliferation by blocking NF-kappaB signaling.
Ying K, Wang C, Liu S, Kuang Y, Tao Q, Hu X. Ying K, et al. Int J Biol Sci. 2022 Jan 1;18(3):1039-1050. doi: 10.7150/ijbs.68312. eCollection 2022. Int J Biol Sci. 2022. PMID: 35173535 Free PMC article.
Colorectal cancer (CRC) is the most common gastrointestinal cancer, with a high mortality rate but limited therapeutic targets. DIRAS family GTPase 2 (DIRAS2) is a member of the Ras-related small G-protein family whose biological functions and underlying mechanism i …
Colorectal cancer (CRC) is the most common gastrointestinal cancer, with a high mortality rate but limited therapeutic targets. DIRAS family …
An engineered cell line with a hRpn1-attached handle to isolate proteasomes.
Negi H, Osei-Amponsa V, Ibrahim B, Evans CN, Sullenberger C, Loncarek J, Chari R, Walters KJ. Negi H, et al. J Biol Chem. 2023 Aug;299(8):104948. doi: 10.1016/j.jbc.2023.104948. Epub 2023 Jun 22. J Biol Chem. 2023. PMID: 37354974 Free PMC article.
Regulated protein degradation in eukaryotes is performed by the 26S proteasome, which contains a 19-subunit regulatory particle (RP) that binds, processes, and translocates substrates to a 28-subunit hollow core particle (CP) where proteo …
Regulated protein degradation in eukaryotes is performed by the 26S proteasome, which contains a 19-subunit r …
cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
Tsurumi C, Shimizu Y, Saeki M, Kato S, Demartino GN, Slaughter CA, Fujimuro M, Yokosawa H, Yamasaki M, Hendil KB, Toh-e A, Tanahashi N, Tanaka K. Tsurumi C, et al. Eur J Biochem. 1996 Aug 1;239(3):912-21. doi: 10.1111/j.1432-1033.1996.0912u.x. Eur J Biochem. 1996. PMID: 8774743 Free article.
Computer-assisted similarity analysis also revealed the high sequence similarity of p97 with a yeast protein whose function is yet unknown, the gene for which is here termed NAS1 (non-ATPase subunit 1). ...These results indicate that p97/Nas1p plays an …
Computer-assisted similarity analysis also revealed the high sequence similarity of p97 with a yeast protein whose function is yet un …
Proteomic Analysis Reveals That Metformin Suppresses PSMD2, STIP1, and CAP1 for Preventing Gastric Cancer AGS Cell Proliferation and Migration.
Wang WH, Chen SK, Huang HC, Juan HF. Wang WH, et al. ACS Omega. 2021 May 26;6(22):14208-14219. doi: 10.1021/acsomega.1c00894. eCollection 2021 Jun 8. ACS Omega. 2021. PMID: 34124444 Free PMC article.
Using small-scale quantitative proteomics, we identified 177 differentially expressed proteins upon metformin treatment; among these, nine proteins such as 26S proteasome non-ATPase regulatory subunit 2 (PSMD2), stress-induc …
Using small-scale quantitative proteomics, we identified 177 differentially expressed proteins upon metformin treatment; among these, nine p …
A viral movement protein targets host catalases for 26S proteasome-mediated degradation to facilitate viral infection and aphid transmission in wheat.
Tian S, Song Q, Zhou W, Wang J, Wang Y, An W, Wu Y, Zhao L. Tian S, et al. Mol Plant. 2024 Apr 1;17(4):614-630. doi: 10.1016/j.molp.2024.03.004. Epub 2024 Mar 7. Mol Plant. 2024. PMID: 38454602
In this study, we investigated the interactions among wheat, barley yellow dwarf virus (BYDV), and its aphid vector and found that the BYDV movement protein (MP) interacts with both wheat catalases (CATs) and the 26S proteasome ubiquitin receptor non- …
In this study, we investigated the interactions among wheat, barley yellow dwarf virus (BYDV), and its aphid vector and found that the BYDV …
Effects of tumor necrosis factor-alpha on the 26S proteasome and 19S regulator in skeletal muscle of severely scalded mice.
Tan Y, Peng X, Wang F, You Z, Dong Y, Wang S. Tan Y, et al. J Burn Care Res. 2006 Mar-Apr;27(2):226-33. doi: 10.1097/01.BCR.0000203378.85736.38. J Burn Care Res. 2006. PMID: 16566573
The monoclonal antibody to TNF-alpha obviously can diminish the increment of the activities and contents of 26S proteasome and 19S regulator as much as the expression levels of the 19S regulator's subunits. The results suggested that TNF-alpha can activate th …
The monoclonal antibody to TNF-alpha obviously can diminish the increment of the activities and contents of 26S proteasome and …
Mts4, a non-ATPase subunit of the 26 S protease in fission yeast is essential for mitosis and interacts directly with the ATPase subunit Mts2.
Wilkinson CR, Wallace M, Seeger M, Dubiel W, Gordon C. Wilkinson CR, et al. J Biol Chem. 1997 Oct 10;272(41):25768-77. doi: 10.1074/jbc.272.41.25768. J Biol Chem. 1997. PMID: 9325304 Free article.
We have isolated a fission yeast gene, mts4(+), by complementation of a temperature-sensitive mutation and show that it encodes subunit 2 (S2) of the 19 S regulatory complex of the 26 S protease. mts4(+) is an essential gene, and we show that loss of this …
We have isolated a fission yeast gene, mts4(+), by complementation of a temperature-sensitive mutation and show that it encodes subunit …